Metabólico
Melanotan - 2
Melanotan-2 es un análogo sintético de la hormona estimulante de los melanocitos alfa estudiado por su interacción con los subtipos de receptores de melanocortina en entornos de laboratorio. Este compuesto se utiliza en investigaciones sobre las vías de señalización de melanocortina y las características de unión a receptores. Suministrado con una pureza ≥99% con verificación por LC-MS y HPLC. Solo para uso en investigación de laboratorio; no destinado al consumo humano ni animal.
Mecanismo de acción
Melanotan-2 is characterized in the literature as a non-selective agonist across the melanocortin receptor family (MC1R, MC3R, MC4R, MC5R), a class of G-protein-coupled receptors. At the melanocortin-1 receptor (MC1R) expressed on melanocytes, research indicates that agonist binding activates adenylyl cyclase and elevates intracellular cAMP, engaging protein kinase A and CREB-dependent upregulation of microphthalmia-associated transcription factor (MITF) and downstream melanogenic enzymes such as tyrosinase — the canonical signaling axis studied in melanogenesis models. Its cyclic lactam constraint and norleucine-for-methionine substitution were designed to increase conformational stability and resistance to oxidative degradation compared with the parent α-MSH sequence.
Beyond MC1R, research indicates that Melanotan-2 activates central melanocortin receptors, notably MC4R and MC3R, which are implicated in preclinical models of energy balance and appetite regulation. In rodent studies, central administration of the peptide has been used to probe melanocortin signaling within discrete brain regions. These observations describe receptor-level pharmacology and signal transduction only; they are presented as mechanistic research context and do not constitute evidence of any therapeutic, cosmetic, or human-use benefit.
Aplicaciones de investigación
- → Characterized in vitro as a non-selective agonist across MC1R, MC3R, MC4R, and MC5R melanocortin receptors.
- → MC1R agonism drives cAMP/PKA-CREB signaling and MITF-mediated tyrosinase expression in melanocyte melanogenesis models.
- → Cyclic lactam bridge (Asp-Lys) and Nle-for-Met substitution engineered to increase conformational rigidity and metabolic stability versus native α-MSH.
- → Used as a reference melanocortin agonist to probe central MC4R/MC3R pathways in rodent energy-balance models.
- → Region-specific central microinjection studies (e.g., nucleus accumbens) employ the peptide to dissect melanocortin control of feeding-related behavior in preclinical models.
Validación analítica
Melanotan - 2 is verified via LC-MS and HPLC analysis. Each lot is tested for identity, purity (≥99% target), and endotoxin levels. Full certificate of analysis is available upon request.
